Element 5 Drugs
von Venice Farr
1. Post synaptic acting drugs
1.1. Non-polarising blockers (competitive antagonists) (reversed by anticholinsterases)
1.1.1. D-tubocurarine
1.1.2. Atracurium
1.1.3. Cisatracurium
1.1.4. Mivacurium
1.2. Depolarising blockers (agonist)
1.2.1. Succinylcholine (suxamethonium)
1.3. Anticholinesterases (if too active)
2. Random
2.1. Aspirin
2.1.1. Materials
2.1.2. Personnel
2.1.3. Services
2.1.4. Duration
2.2. Diazepam
2.3. Tetradoxin
2.4. Prozac/Fluoxetine
2.5. Sildenafil/Viagra
3. Presynaptic acting drugs
3.1. Hemicholinium/Triethylcholine
3.2. Vesamicol
3.3. Botulinum toxin (Botox)
3.4. α-latrotoxin
4. Parasympathomimetics
4.1. Muscarinic receptor agonists
4.1.1. Selective
4.1.1.1. Cevimeline (M3)
4.1.2. Non-selective
4.1.2.1. Muscarine
4.1.2.2. Bethanechol
4.1.2.3. Carbachol
4.1.2.4. Acetylcholine
4.2. Anticholinesterases
4.2.1. Short acting- Edrophonium
4.2.2. Medium acting- Neostigmine
4.2.3. Irreversible - dyflos
5. Parasympatholytics
5.1. Muscarinic anatagonists (competitive antagonists)
5.1.1. Atropine
5.1.2. Hyoscine
5.1.3. Ipratropium
5.1.4. Pirenzepine
6. Mixed α antagonists
6.1. Phenoxybenzamine = irreversible
6.2. Phentolamine = reversible
7. α1 antagonist
7.1. Prazosin
8. β1 and β2 antagonist
8.1. Propranolol
9. β1 >>> β2 antagonist
9.1. Atenolol
10. α1 and β1 antagonist
10.1. Carvedilol
11. Reversible competitive antaganonists
11.1. Propranolol
11.2. Haloperidol
11.3. Atropine
11.4. Ranitidine
11.5. (D-)tubocurarine
12. Drugs effecting the synthesis of NA
12.1. α-metirosine
12.2. Carbidopa/Benserazide
13. Drugs affecting uptake 1 (NA)
13.1. Tricyclic antidepressants - imipramine
13.2. Cocaine
13.3. Amphetamine, phenoxybenzamine, guanethidine (=noradrenergic neurone blocker)
14. Drugs effecting uptake 2 (NA)
14.1. Phenoxybenzamine
15. Displacing agents (NA)
15.1. Ephedrine
15.2. Pseudoephedrine
15.3. Amphetamine, Metamphetamine, Ecstasy (MDMA)
15.4. Tyramine in food
16. Mixed Agonist (all α and β)
16.1. Adrenaline
17. α1 agonists
17.1. Phenylephrine
17.2. Xylometazoline & Oxymetazoline
17.3. Metaraminol
18. α2 agonists
18.1. Clonidine
18.2. Moxonidine
18.3. Methyldopa (and reduces NA)
19. Mixed β agonists
19.1. Isoprenaline (all β)
19.2. Dobutamine (β1 and α1)
19.3. Dopamine (β1 and α1)
20. β2 agonists
20.1. Salbutamol & Terbutaline
21. MAO Inhibitors (antidepressants)
21.1. Reversible inhibitors
21.1.1. Moclobemide
21.2. Irreversible inhibitors
21.2.1. Phenelzine
21.2.2. Tranylcypromine
21.2.3. Isocarboxazid