Sepsis

1. Pathology

1.1. Source of infection

1.2. Neuroendocrine system

1.2.1. Cortisol

1.2.2. Epinephrine

1.2.3. Norepinephrine

1.3. Bacterial toxins released

1.3.1. Lactic Acid

1.4. Damage to endothelium

1.4.1. Release of platelets

1.4.2. Release of thromnboplastin

1.5. Inflammatory Mediators

1.5.1. Complement and Interleukins

1.5.1.1. Depressed Myocardial Contractility

2. Diagnosis

2.1. Early detection

2.1.1. Serum Lactic Acid

2.1.2. Troponin

2.1.3. C-reactive protein

2.1.4. Prcalcitonin

2.1.5. CBC

2.1.6. CMP

2.1.7. Blood Cultures

3. Treatment

3.1. RSRB

3.2. Initiation of IV Antibiotics

3.3. Anti-hypotensives

3.4. O2

3.5. Hospitalization

4. Clinical Presentation

4.1. Early

4.1.1. Inflammation

4.1.2. Decreased perfusion

4.1.3. Alteration in Cellular O2

4.1.4. Tachycardia

4.1.5. Fever

4.1.6. Altered Mental Status

4.2. Late

4.2.1. Hematologic Failure

4.2.2. Myocardial Failure

4.2.2.1. Hypotension

4.2.3. Bradycardia

4.2.4. Encephalopathy

4.2.5. Seizures

5. Epidemiology

5.1. Bacterial infection

5.2. Any age group

5.3. Men and women

6. Risk Factors

6.1. Age

6.2. Cancer Patients

6.3. Diabetes

6.4. Chronic UTI